RADIL Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 202841AP
DescriptionRadil is a broadly expressed adapter protein that contains a RA-like domain, a PDZ domain and a DIL domain. Like RAPL and RIAM, Radil interacts preferentially with active GTP-bound Rap1, and overexpression of Radil enhances integrin-mediated adhesion. In addition, Radil knock down inhibits cell-substrate adhesion in HT1080, AD293, and NMuMG cells and results in migration defects in SW1353 and zebrafish neural crest cells. Radil regulates neutrophil adhesion by specifically enhancing beta2-integrin activation, as well as focal adhesion kinase (FAK) and paxillin phosphorylation.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|RADIL Fusion Protein Ag13996|
|Antigen Affinity Chromatography|
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