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Invitrogen™ RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

Manufacturer:  Invitrogen™ PV3805

Encompass

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Catalog No. PV3805


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Description

Description

RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylates and activates the serine⁄threonine specific protein kinases ERK1 and ERK2. The RAF1 Y340D Y341D mutant is constitutively active.
Specifications

Specifications

NP_002871, Y340D, Y341D
66.4 kDa
RAF1 (cRAF) Y340D Y341D
aa 306-648; Y340D, Y341D
GST Tag
Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Dry Ice
RAF1 (cRAF) Y340D Y341D
Baculovirus
Recombinant, Catalytic, Mutant
Serine/Threonine Kinases
Human
4773, 5894
10μg
RAF Kinase Family
Yes
Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Ser⁄Thr Kinases: TKL Group
LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
v-raf-1 murine leukemia viral oncogene homolog 1
Kinases & Inhibitors
Liquid
Kinase Assay
Signal Transduction
SDS
Documents

Documents

Product Certifications
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For Research Use Only. Not for use in diagnostic procedures.