Invitrogen™ RALA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522333

Catalog No. PIPA522333

Description

Recommended positive controls: HepG2, mouse brain, rat lung. Predicted reactivity: Mouse (99%), Rat (99%), Drosophila (86%), Xenopus laevis (97%), Rhesus Monkey (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Specifications

• Antigen: RALA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rala
• Gene Alias: 3010001O15Rik; AW322615; MGC48949; Ral; -ral simian leukemia viral oncogene homolog A (ras related); RALA; Ral-a; ral-A protein; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; ras related GTP binding protein A; Rasl1; RAS-like protein A; RAS-like, family 1; ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56044, 5898, 81757
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.55 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P11233, P63321, P63322
• Gene Symbols: Rala
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 206 of RALA (Uniprot ID#P11233).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Amphibian, Rodent
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov