RALA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5119782

Catalog No. PIPA5119782

Description

Positive Control: HepG2 cell lysate, Jurkat cell lysate, Hela cell lysate, mouse liver tissue lysate, rat thymus tissue lysate, A431, F9, rat brain tissue, mouse brain tissue. Subcellular Location: Cell membrane, Membrane.

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Specifications

• Antigen: RALA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rala
• Gene Alias: 3010001O15Rik; AW322615; MGC48949; Ral; -ral simian leukemia viral oncogene homolog A (ras related); RALA; Ral-a; ral-A protein; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; ras related GTP binding protein A; Rasl1; RAS-like protein A; RAS-like, family 1; ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 56044, 5898, 81757
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P11233, P63321, P63322
• Gene Symbols: Rala
• Immunogen: Recombinant full length protein of human RALA
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG