RANGAP1 Mouse anti-Canine, Human, Rat, Clone: OTI1B4, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA501265

Catalog No. 50-167-2408

Description

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Specifications

• Antigen: RANGAP1
• Classification: Monoclonal
• Concentration: 0.81 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P46060
• Gene Symbols: RANGAP1
• Immunogen: Full length human recombit protein of human RANGAP1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1B4
• Conjugate: Unconjugated
• Gene: RANGAP1
• Gene Alias: Fug1, RANGAP, SD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 362965, 481234, 5905
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid