Invitrogen™ RANGAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA592435

Catalog No. PIPA592435

Description

Immunogen sequence: PQQRGQGEKS ATPSRKILDP NTGEPAPVLS SPPPADVSTF LAFPSPEKLL RLGPKSSVLI AQQTDTSDPE KVVSAFLKVS SVFKDEATVR MAVQDAVDAL MQKAFNSSSF NSNTFLTRLL VHMGLLKSED KVKAIANLYG PLMALNHMVQ QDYFPKALAP LLLAFVTKPN SALESCSFAR HSLLQTLYKV; Positive Samples: BT-474, HeLa, MCF7, A-549, Jurkat; Cellular Location: Chromosome, Cytoplasm, Cytoplasmic side, Nucleus membrane, Peripheral membrane protein, centromere, cytoskeleton, kinetochore, spindle pole.

Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.

Specifications

• Antigen: RANGAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RANGAP1
• Gene Alias: C79654; fug1; KIAA1835; MGC20266; mKIAA1835; RAN GTPase activating protein 1; RAN GTPase activating protein 1 a; Ran GTPase activating protein 1 b; Ran GTPase activating protein 1 L homeolog; Ran GTPase activating protein 1 S homeolog; ran GTPase-activating protein 1; RANGAP; RanGAP1; rangap1.L; rangap1.S; rangap1a; rangap1-a; rangap1b; rangap1-b; rna1p; SD; segregation distorter homolog; segregation distortion; XELAEV_18023679mg; XELAEV_18025680mg
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19387, 5905
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P46060, P46061
• Gene Symbols: RANGAP1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 398-587 of human RanGAP1 (NP_0028741).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov