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RAP1 / TERF2IP Mouse anti-Human, Clone: 4C8, Active Motif™

Mouse Monoclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 61236

Encompass

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Catalog No. 50-199-3257


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Description

Description

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Specifications

Specifications

RAP1 / TERF2IP
Western Blot
1 mg/mL
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Q9NYB0
dopamine receptor interacting protein 5; Dopamine receptor-interacting protein 5; DRIP5; hRap1; MNCb-0448; MNCb-0628; PP8000; Rap1; RAP1 homolog; Repressor/activator protein 1 homolog; tel; telomeric repeat binding factor 2, interacting protein; Telomeric repeat-binding factor 2-interacting protein 1; TERF2 interacting protein; TERF21P; TERF2-interacting telomeric protein 1; Terf2ip; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein Rap1; TRF2-interacting telomeric RAP1 protein
This RAP1 / TERF2IP antibody was raised against a protein corresponding to full-length human RAP1 / TERF2IP.
Protein G
RUO
Antibody
Monoclonal
Human
TERF2IP
4C8
Unconjugated
TERF2IP
Liquid
Mouse
IgG2b
10 μg
-20°C, Avoid Freeze/Thaw Cycles
Primary
54386
SDS
Documents
Product Certifications
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