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RAP1 / TERF2IP Mouse anti-Human, Clone: 4C8, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$116.85 - $356.95

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen RAP1 / TERF2IP
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3257 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61236
10 μg
Each for $116.85
Add to cart
 
50-199-3256 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61235
100 μg
Each for $356.95
Add to cart
 
Description

Description

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
Specifications

Specifications

Monoclonal
Primary
RAP1 / TERF2IP
Unconjugated
SDS
Product Certifications
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