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RAP80 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Thermo Scientific PA598798

Catalog No. PIPA598798



Description

Description

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
Specifications

Specifications

RAP80
Polyclonal
Unconjugated
UIMC1
Liquid
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
290997, 51720
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
2.99 mg/mL
PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
Q5PQK4, Q96RL1
Uimc1
Recombit Human BRCA1-A complex subunit RAP80 protein (161-235AA)
Protein G
RUO
Antibody
Polyclonal
Human, Rat
Documents
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