Invitrogen™ RASGRP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5107232

Catalog No. PIPA5107232

Description

Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 79%; Rabbit: 79%; Rat: 93%.

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.

Specifications

• Antigen: RASGRP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RASGRP1
• Gene Alias: Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CALDAG-GEFII; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; hRasGRP1; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1; RASGRP; RASGRP1; V
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10125
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: O95267
• Gene Symbols: RASGRP1
• Immunogen: Synthetic peptide located within the following region: LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov