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CD115 Rat anti-Mouse, PE, Clone: T38-320, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 565249

Catalog No. BDB565249


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Description

Description

The T38-320 monoclonal antibody specifically binds to CD115 which is also known as Colony stimulating factor 1 Receptor (CSF-1R) or Macrophage colony-stimulating factor 1 receptor (M-CSFR). This type I transmembrane glycoprotein is a receptor tyrosine kinase (RTK) that belongs to the Ig superfamily. It is expressed on a variety of cells including those committed to the mononuclear phagocyte lineage, such as, monocytes, macrophages, and osteoclasts. CSF-1 binds to and signals through CSF-1R homodimers which undergo tyrosine autophosphorylation and transduce downstream signaling pathways resulting in cytoskeletal reorganization and gene expression. CSF-1R activation stimulates the proliferation, differentiation, and survival of cells within the mononuclear phagocyte system. Interleukin-34 (IL-34) is another ligand for CD115 that can induce similar, as well as, some different biological responses by CD115-positive target cells.

Specifications

Specifications

CD115
T38-320
PE
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Rat
IgG1, κ
0.1mg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
M-CSFR; M-CSF-R; CSF-1 Receptor; CSF-1R; Csf1r; Csfmr; Fms; c-Fms; Fim-2
Affinity Purified
Mouse CD115 Recombinant Protein
Affinity Chromatography
RUO
Primary
Murine
Documents
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