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IL-2 Rat anti-Mouse, APC-R700, Clone: JES6-5H4, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 565186

Catalog No. BDB565186


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Description

Description

The JES6-5H4 monoclonal antibody specifically binds to mouse interleukin-2 (IL-2). IL-2 is a multifunctional cytokine that plays pivotal roles in immunity and tolerance. It is produced by activated T cells. IL-2 effects the activation, growth, proliferation and/or differentiation of various cell types including T and B lymphocytes and their precursors, LAK cells, NK cells, and monocytes/macrophages. IL-2 mediates its biological activities by binding to IL-2 receptor compleses. The intermediate affinity IL-2R is comprised of IL-2R β (CD122) and common gamma chain ( γc; CD132) subunits whereas the high-affinity IL-2R is comprised of IL-2R α (CD25), IL-2R β and γc subunits. The JES6-5H4 monoclonal antibody binds to IL-2 and neutralizes its biological activity.

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

Specifications

Specifications

IL-2
JES6-5H4
APC-R700
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Rat
IgG2b
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry, Immunocytochemistry
0.2mg/mL
Il2; Interleukin-2; T-cell growth factor; TCGF
Affinity Purified
Mouse IL-2 Recombinant Protein
Affinity Chromatography
RUO
Primary
Murine
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