CD106 Rat anti-Mouse, Brilliant Violet 786, Clone: 429 (MVCAM.A), BD Optibuild™

Rat Monoclonal Antibody

Supplier:  BD Biosciences 740865

Catalog No. BDB740865

Description

The 429 monoclonal antibody specifically binds to both the long (∽110 kDa) transmembrane-spanning form and the truncated (∽47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 ( α 4β 1 integrin) and LPAM-1 ( α 4β 7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was the mouse preadipose cell line PA6.

Specifications

• Antigen: CD106
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Vcam-1; Vascular cell adhesion molecule 1; Vascular cell adhesion protein 1
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: 429 (MVCAM.A)
• Conjugate: Brilliant Violet 786
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse preadipose cell line PA6
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only