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CD106 Rat anti-Mouse, Brilliant Violet 786, Clone: 429 (MVCAM.A), BD Optibuild™

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 740865

Catalog No. BDB740865


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Description

Description

The 429 monoclonal antibody specifically binds to both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 ( α 4β 1 integrin) and LPAM-1 ( α 4β 7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was the mouse preadipose cell line PA6.

Specifications

Specifications

CD106
429 (MVCAM.A)
Brilliant Violet 786
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Vcam-1; Vascular cell adhesion molecule 1; Vascular cell adhesion protein 1
Affinity Purified
Mouse preadipose cell line PA6
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
Documents
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