CD172a Rat anti-Mouse, Brilliant Violet 510, Clone: P84, BD Optibuild
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740159
The P84 monoclonal antibody specifically binds to CD172a, also known as SIgnal-Regulatory Protein α (SIRP α ), Src Homology 2 domain-containing protein tyrosine Phosphatase (SHP) Substrate 1 (SHPS-1), or Brain Immunoglobulin-like molecule with Tyrosine-based activation motifs (BIT). CD172a is an adhesion molecule of the Ig superfamily which is expressed on neurons in the central nervous system and the retina, on macrophages, and on bone-marrow myeloid cells. Its ligand, CD47, or Integrin-Associated Protein (IAP), is expressed by a wide variety of cells. CD172a and CD47 are proposed to mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages.
The antibody was conjugated to BD Horizon BV510 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.
|Brilliant Violet 510|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Sirpa; Sirp alpha; Sirpα; Bit; SHPS-1; p84; Ptpns1|
|Membrane fractions from mouse brain|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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