CD196 (CCR6) Rat anti-Mouse, Brilliant Violet 711, Clone: 140706, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740646
The 140706 monoclonal antibody specifically binds to mouse CD196 (CCR6), a CC chemokine receptor that is expressed on B lymphocytes and subsets of T and dendritic cells. The known ligand for CCR6 is CCL20/MIP-3 α , and together they regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses.
The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
|Brilliant Violet 711|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|CCR6, BN-1, CKR-L3, DRY6, KY411, GPR-CY4, STRL22|
|Mouse CCR6-transfected Rat Cell Line|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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