CD278 Rat anti-Mouse, Brilliant Violet 711, Clone: 7E.17G9, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740763
The 7E.17G9 monoclonal antibody specifically binds to CD278, the I nducible Cos timulatory molecule (ICOS), a 47-57 kDa homodimeric glycoprotein of the CD28 family of costimulatory molecules. ICOS is expressed on subpopulations of CD4-CD8- and CD4+CD8- (but not CD4-CD8+ or CD4+CD8+) thymocytes, on some T-cell lines, and on small numbers of peripheral leukocytes. It is upregulated on T lymphocytes following activation via the T-cell receptor. The T-cell activation marker H4 is the same molecule as ICOS. ICOS is a costimulatory receptor, and its ligand on antigen-presenting cells has been called B7RP-1, GL50, B7h, B7-H2, or LICOS. There is considerable evidence that the interaction of ICOS with its ligand is involved in the regulation of many, but not all, T-cell-mediated immune responses.
|Brilliant Violet 711|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|ICOS; Ailim; CCLP; CRP-1; Ly115; Inducible T-cell costimulator|
|Mouse Icos cDNA and ICOS hexahistidine fusion protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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