CD49d Rat anti-Mouse, Brilliant Violet 421, Clone: R1-2, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740012
The R1-2 monoclonal antibody specifically binds to α 4 chain (CD49d), which is expressed as a heterdimer with either of two β , β 1 or β 7 (also known as β p). The α 4β α 4β 7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. The R1-2 antibody blocks some α 4 integrin-mediated binding functions. In combination with mAb 9C10 (MFR4.B) (Cat. No. 553313), binding of VLA-4 expressing cells to VCAM-1 can be almost completely inhibited.
|Brilliant Violet 421|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|IgG2b, κ, also known as Fischer, CDF IgG2b, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Integrin α4; Itga4; Integrin alpha-4; LPAM alpha; VLA-4 alpha; VLA-4a|
|AKR/Cum mouse spontaneous T lymphoma line TK1|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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