LPAM-1 Rat anti-Mouse, Brilliant Violet 650, Clone: DATK32, BD Optibuild
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740493
The DATK32 monoclonal antibody specifically binds to an epitope specific for the α 4β 7 integrin heterodimer. α 4β 7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells. It interacts with several ligands, including VCAM-1 (CD106), fibronectin, and MAdCAM-1. DATK32 antibody induces α 4β 7-dependent lymphocyte aggregation, but it inhibits other α
The antibody was conjugated to BD Horizon BV650 which is part of the BD Horizon Brilliant Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|CDF IgG2a, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Itga4Itgb7; α4β7 Integrin; alpha 4 beta 7 integrin; CD49dβ7|
|AKR/Cum mouse T lymphoma line TK1|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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