LPAM-1 Rat anti-Mouse, Brilliant Violet 650, Clone: DATK32, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740493
The DATK32 monoclonal antibody specifically binds to an epitope specific for the α 4β 7 integrin heterodimer. α 4β 7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells. It interacts with several ligands, including VCAM-1 (CD106), fibronectin, and MAdCAM-1. DATK32 antibody induces α 4β 7-dependent lymphocyte aggregation, but it inhibits other α
The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|IgG2a, κ, also known as Fischer, CDF IgG2a, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Itga4Itgb7; α4β7 Integrin; alpha 4 beta 7 integrin; CD49dβ7|
|AKR/Cum mouse T lymphoma line TK1|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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