AID Rat anti-Human, Unlabeled, Clone: EK2-5G9, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 565784
The EK2-5G9 monoclonal antibody specifically binds to human Activation-induced cytidine deaminase (AICDA), also known as AID, or Single-stranded DNA cytosine deaminase. AID is an enzyme that preferentially acts upon certain DNA sequence motifs, such as those located in immunoglobulin variable regions, to induce cytidine-to-uracil mutations. AID-induced mutations initiate both somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin genes in activated B cells during immune responses. While essential for immunoglobulin gene diversification, dysregulated AID activity can result in genomic instability and oncogenic transformation. Originally thought to be B-cell specific, AID now appears to be abnormally expressed in several epithelial cancers. AID may also play roles in DNA demethylation.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C|
|Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot|
|AID; ARP2; CDA2; HEL-S-284; HIGM2; Cytidine aminohydrolase|
|Human AID (185-198) Peptide|
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