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AID Rat anti-Human, Unlabeled, Clone: EK2-5G9, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 565784

Catalog No. BDB565784


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Description

Description

The EK2-5G9 monoclonal antibody specifically binds to human Activation-induced cytidine deaminase (AICDA), also known as AID, or Single-stranded DNA cytosine deaminase. AID is an enzyme that preferentially acts upon certain DNA sequence motifs, such as those located in immunoglobulin variable regions, to induce cytidine-to-uracil mutations. AID-induced mutations initiate both somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin genes in activated B cells during immune responses. While essential for immunoglobulin gene diversification, dysregulated AID activity can result in genomic instability and oncogenic transformation. Originally thought to be B-cell specific, AID now appears to be abnormally expressed in several epithelial cancers. AID may also play roles in DNA demethylation.

Specifications

Specifications

AID
EK2-5G9
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2b, κ
0.1mg
Store undiluted at 4°C
Monoclonal
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
0.5mg/mL
AID; ARP2; CDA2; HEL-S-284; HIGM2; Cytidine aminohydrolase
Affinity Purified
Human AID (185-198) Peptide
Affinity Chromatography
RUO
Primary
Human
Documents
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