MilliporeSigma™ Rat anti-Septin-9, Clone: 1A6C2,

Rat Monoclonal Antibody

Supplier:  MilliporeSigma™ MABT321

Catalog No. MABT321MI

Description

Specifically detects Septin-9 clone: 1A6C2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Septin-9 (also known as eighth septin, Eseptin, and MLL septin-like fusion) is encoded by the Sept9 gene in rat and mouse (SEPT9 in human). Septins are GTP-binding proteins capable of forming higher-order oligomers and filamentous polymers that contact with the cell membrane and cytoskeleton. Septins are involved in various cellular processes, including cytokinesis, karyokinesis, exocytosis, and cell shape maintenance. The expression of SEPT2, SEPT6, SEPT7 and SEPT9 in heart tissue is reported to correlate well with cardiomyocyte cytokinesis activity during heart development, is highly expressed in embryonic heart, downregulated around birth, and nondetectable in the adult heart. (PMID 16739252 & 24837489). Clone 1A6C2 was generated using an immunogen sequence present only in rat spetin-9 isoform 1 (SLP-a; Q9QZR6), but missing in rat isoform 2-4 (SLP-b, E-septin long & short forms). The immunogen sequence is 100% conserved in murine species (A2A6U3) and differs by one amino acid when compared to the corresponding human sequence in isoform 2, and missing in human isoforms 1,3,4 (Q9UHD8).

Specifications

• Antigen: Septin-9
• Classification: Monoclonal
• Formulation: Purified rat monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: 41891
• Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of rat Septin-9.
• Quantity: 100 μg
• Research Discipline: Cell Structure
• Gene ID (Entrez): NP_001106969
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2a κ

• Applications: Immunocytochemistry, Western Blot
• Clone: 1A6C2
• Gene Accession No.: Q9QZR6
• Host Species: Rat
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Purified

For Research Use Only