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Rat IL-1 beta (aa 117-268), Recombinant Protein, Invitrogen™ Non-distribution product as customer accommodation.

E. coli Recombinant Protein

$238.00 - $3850.00

Specifications

Recombinant Yes
Name Rat IL-1 beta (aa 117-268)
For Use With (Application) Control, ELISA, Western Blot
Concentration 200 µg/mL
Conjugate Unlabeled
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Products 4
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIRP87920 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87920
10 µg
Each for $238.00
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PIRP87921 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87921
25 µg
Each for $443.00
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PIRP87922 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87922
100 µg
Each for $1,278.00
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PIRP87923 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87923
500 µg
Each for $3,850.00
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Description

Description

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

Yes
Control, ELISA, Western Blot
Unlabeled
PBS with no preservative; pH 7.2
E. coli
-20°C
Q63264
IL1B
>95%
Rat IL-1 beta (aa 117-268)
200 µg/mL
Liquid
catabolin; cytokine; il 1 b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; Il-1 b; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 beta-like; Interleukin-1 b; interleukin-beta; LOC100052414; lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
RUO
Rat
24494
17.4 kD
SDS
Product Certifications
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