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Invitrogen™ Rat SCF ELISA Kit

Rat SCF quantitates rat SCF in serum, plasma, supernatant.

Manufacturer:  Invitrogen™ ERA53RBX5

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Catalog No. ERA53RBX5


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Description

Description

Rat SCF quantitates rat SCF in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat SCF.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Specifications

Specifications

ELISA
710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; mast cell growth factor; Mgf; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Biotin
P21581
Research Use Only
2°C to 8°C
4 hr 45 min
<12%
5 x 96 Tests
12 pg/mL
Colorimetric Microplate Reader
HRP
12 to 3,000 pg/mL
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Supernatant, 50 µL; Plasma, 50 µL; Serum, 50 µL
1 hr 20 min
SCF
<10%
Serum, Plasma, Supernatant
KITLG
SDS
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