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RCAN1 Mouse anti-Human, Mouse, Clone: OTI10C6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527304

Catalog No. PIMA527304


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Description

Description

The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. This antibody is specific for Isoform RCAN1-1L, which is overexpressed in Alzheimer ft.s Disease (Harris, C.D. et al) and is downregulated in Huntington ft.s Disease (Ermak, G. et al). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Specifications

Specifications

RCAN1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P53805, Q9JHG6
ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1, Down syndrome candidate region 1, Down syndrome critical region gene 1, calcipressin-1, calcium and oxidant-inducible mRNA, down syndrome critical region protein 1, modulatory calcineurin-interacting protein 1, myocyte-enriched calcineurin-interacting protein 1, near DSCR proline-rich protein
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1827, 54720
Western Blot
OTI10C6
Unconjugated
RCAN1
Liquid
Rcan1
Full length human recombit protein of RCAN1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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