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RCAN2 Mouse anti-Human, Clone: 1A9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524549

Catalog No. PIMA524549


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Description

Description

Peptide Sequence: KAEELHYPLG ERRSDYDREA LLGVQEDVDE YVKLGHEEQQ KRLQAIIKKI DLDSDGFLTE SELSSWIQMS FKHYAMQEAK QQFVEYDKNS DDTVTWDEYN IQMYDRVIDF DENTALDDAE EESFRKLHLK DKKRFEKANQ DSGPGLSLEE FIAFEHPEEV DYMTEFVIQE ALEEHDKNGD GFVSLEEFLG DYRWDPTANE DPEWILVEKD RFVNDYDKDN DGRLDPQELL PWVVPNNQGI AQEEALHLID EMDLNGDKKL SEEEILENPD LFLTSEATDY GRQLHDDYFY HDEL

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin ft.s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
Specifications

Specifications

RCAN2
Monoclonal
Unconjugated
RCAN2
Liquid
RCAN2
RCN2 (AAH04892.1, 24 a.a. ∽ 317 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Protein A
RUO
Antibody
Monoclonal
Human
ELISA, Western Blot
1A9
PBS with no preservative; pH 7.4
Q14206
Csp2, Dscr1l1, MCIP2, ZAKI-4; Down syndrome critical region gene 1-like 1; calcineurin inhibitory protein ZAKI-4; calcipressin-2; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2
Mouse
IgG1, kappa
100 μg
-20° C
Primary
10231
Documents
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