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Tocris Bioscience™ RECTAS
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IKBKAP pre-mRNA splicing modulator

$212.50 - $891.50

Specifications

Chemical Name or Material 2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
CAS 101862-47-9
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C10H8ClN5O
Purity 0.98
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
76-791-0
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Tocris Bioscience™
7679/10
10 mg
Each for $212.50
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76-795-0
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Tocris Bioscience™
7679/50
50 mg
Each for $891.50
Add to Cart
 
Description

Description

RECTAS (rectifier of aberrant splicing) is a pre-mRNA splicing modulator of the IKBKAP (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase complex associated protein) gene. It corrects aberrant IKBKAP splicing in vitro in cellular models of familial dysautonomia and in vivo in transgenic mice. In combination with Phenylbutyric acid (Cat. No. 2682), RECTAS rescues PARK7 aberrant splicing and neuronal cell loss in a midbrain organoid model of familial Parkinson's disease. Orally bioavailable and brain penetrant.
Specifications

Specifications

2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
DNA, RNA and Protein Synthesis Compounds
0.98
101862-47-9
C10H8ClN5O
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

SDS
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Documents

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