REST Mouse anti-Human, Clone: CL0381, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524606
Immunogen sequence: SPPLPKENLR EEASGDQKLL NTGEGNKEAP LQKVGAEEAD ESLPGLAANI NESTHISSSG QNLNTPEGET LNGKHQTDSI VCEMKMDTDQ NTRENLTGIN STVEEPVSPM LPPSAVEERE AVSKTALA Highest antigen sequence identity to the following orthologs: Mouse - 41%, Rat - 43%. Binds to an epitope located within the peptide sequence ISSSGQNLNT as determined by overlapping synthetic peptides.Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|NRSF, XBR, X2 box repressor; neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Recombit protein corresponding to Human REST|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
Research Use Only