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REST Mouse anti-Human, Clone: CL0381, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524606

Catalog No. PIMA524606


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Description

Description

Immunogen sequence: SPPLPKENLR EEASGDQKLL NTGEGNKEAP LQKVGAEEAD ESLPGLAANI NESTHISSSG QNLNTPEGET LNGKHQTDSI VCEMKMDTDQ NTRENLTGIN STVEEPVSPM LPPSAVEERE AVSKTALA Highest antigen sequence identity to the following orthologs: Mouse - 41%, Rat - 43%. Binds to an epitope located within the peptide sequence ISSSGQNLNT as determined by overlapping synthetic peptides.

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Specifications

Specifications

REST
Monoclonal
0.7 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q13127
NRSF, XBR, X2 box repressor; neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5978
Immunohistochemistry
CL0381
Unconjugated
REST
Liquid
REST
Recombit protein corresponding to Human REST
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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