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Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Specifications

Antigen Retinoblastoma (Rb) Ab-5
Clone XZ133
Applications Immunofluorescence, Immunoprecipitation
Classification Monoclonal
Conjugate Unconjugated
View More Specs

Products 1
Catalog Number Mfr. No. Concentration Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Quantity Price Quantity & Availability  
MS595P0
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Thermo Scientific™
MS595P0
200μg/mL 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Host Species: Mouse

Clone: XZ133

Isotype: IgG1

Species Reactivity: Human, Mouse (strong) and Chicken (strong). Does not react with Xenopus. Others not known.

Epitope: aa 620-665

Immunogen: Recombinant human Rb protein corresponding to amino acids 387-928

Molecular Weight: 105kDa

Positive Control: Ls174T, HT29, HUVEC cells

Cellular Localization: Nuclear Ab-5 reacts with the hyperphosphorylated as well as the under phosphorylated form of the Rb protein.

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Retinoblastoma (Rb) Ab-5
Immunofluorescence, Immunoprecipitation
Unconjugated
Murine
Cancer and Tumor Biology
Recombinant human Rb protein corresponding to amino acids 387-928
XZ133
Monoclonal
Concentrated
RUO
Primary
IgG1
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