Tocris™ Reversan

Selective MRP1 and P-gp inhibitor

Manufacturer: Tocris™ 3722/50

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Catalog No. 37-225-0R

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Reversan
    Inhibitors Reversan
    Purity >99
    Molecular Weight 441.52
    Quantity 50mg

    Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

    • Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
    • Formula: C26H27N5O2
    • CAS Number: 313397-13-6
    • Solubility: Soluble to 25mM in DMSO
    • Purity: >99

  • Description & Specifications

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