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RFWD3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550121

Catalog No. PA550121


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Description

Description

The antibody detects endogenous levels of total RFWD3 protein.

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
Specifications

Specifications

RFWD3
Polyclonal
Unconjugated
RFWD3
Liquid
RFWD3
Synthesized peptide derived from internal of human RFWD3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q6PCD5
RNF201
Rabbit
IgG
100 μL
-20°C
Primary
55159
Documents
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