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RGMA Mouse anti-Human, Clone: OTI4G8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527491

Catalog No. PIMA527491


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Description

Description

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Specifications

Specifications

RGMA
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96B86
RGM domain family member A; RGM domain family; member A; RGMrepulsive guidance molecule A
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
56963
Immunohistochemistry (Paraffin)
OTI4G8
Unconjugated
RGMA
Liquid
RGMA
Human recombit protein fragment corresponding to amino acids 169-424 of RGMA produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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