RGMA Mouse anti-Human, Clone: OTI4G8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527491
DescriptionMember of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RGM domain family member A; RGM domain family; member A; RGMrepulsive guidance molecule A|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 169-424 of RGMA produced in E.coli|
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