Invitrogen™ RGS13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140287

Catalog No. PIPA5140287

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: TYKKIASRWS RISRAKKLYK IYIQPQSPRE INIDSSTRET IIRNIQEPTE TCFEEAQK.

RGS13 is the smallest member of the mammalian gene family, RGS (regulators of G protein-signaling) which are structural and functional homologues of yeast SST2 and C. elegans egl-10 proteins. RGS proteins attenuate G protein-mediated pathways by acting as GTPase-activating proteins (GAPs) for Ga subunits. RGS13 has been found most abundantly in human tonsil, thymus, lung, lymph node, and spleen. RGS13 regulate Gai, Gaq, and Gas coupled signaling cascades. It is a GTPase-activating protein for Gai and Gao. The protein blocks MAPK activity induced by Gai- or Gaq-coupled receptors. The protein also attenuates GTPase-deficient Gaq (GaqQL) mediated cAMP response element activation. The gene encoding for human RGS13 is localized on chromosome 1q31.2.

Specifications

• Antigen: RGS13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RGS13
• Gene Alias: MGC17173; regulator of G protein signaling 13; regulator of G-protein signaling 13; regulator of G-protein signalling 13; RGD1562103; Rgs13; RP11-92K2.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6003
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14921
• Gene Symbols: RGS13
• Immunogen: Recombinant protein corresponding to Human RGS13. Recombinant protein control fragment (Product #RP-109576).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG