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RGS13 Mouse anti-Human, Clone: OTI5D7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527213
DescriptionRGS13 is the smallest member of the mammalian gene family, RGS (regulators of G protein-signaling) which are structural and functional homologues of yeast SST2 and C. elegans egl-10 proteins. RGS proteins attenuate G protein-mediated pathways by acting as GTPase-activating proteins (GAPs) for Ga subunits. RGS13 has been found most abundantly in human tonsil, thymus, lung, lymph node, and spleen. RGS13 regulate Gai, Gaq, and Gas coupled signaling cascades. It is a GTPase-activating protein for Gai and Gao. The protein blocks MAPK activity induced by Gai- or Gaq-coupled receptors. The protein also attenuates GTPase-deficient Gaq (GaqQL) mediated cAMP response element activation. The gene encoding for human RGS13 is localized on chromosome 1q31.2.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RGS13; regulator of G-protein signaling 13; MGC17173; regulator of G-protein signalling 13|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of RGS13 produced in E.coli|
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