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RHBDD1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 208691AP

Catalog No. 50-173-3127


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Description

Description

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
Specifications

Specifications

RHBDD1
0.21 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q4V8F3, Q8BHC7, Q8TEB9
HSD 50, RHBDD1, rhomboid domain containing 1
Rabbit
IgG
150 μL
-20°C
Primary
316557, 76867, 84236
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RHBDD1
Liquid
Rhbdd1
RHBDD1 Fusion Protein Ag14932
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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