RHBDD1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 208691AP
DescriptionThe Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Q4V8F3, Q8BHC7, Q8TEB9|
|HSD 50, RHBDD1, rhomboid domain containing 1|
|316557, 76867, 84236|
|Immunohistochemistry (Paraffin), Western Blot|
|RHBDD1 Fusion Protein Ag14932|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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