Tocris™ Rhosin hydrochloride

Rho GTPase inhibitor

Manufacturer: Tocris™ 5003/50

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Catalog No. 50-035-0R

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Rhosin hydrochloride
    Inhibitors Rhosin hydrochloride
    Purity >98
    Molecular Weight 394.86
    Quantity 50mg

    Rho GTPase inhibitor (Kd = 354nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

    • Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
    • Formula: C20H18N6O.HCl
    • CAS Number: 1281870-42-5
    • Solubility: Soluble to 20mM in water with gentle warming and to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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