Tocris Rhosin hydrochloride
Rho GTPase inhibitor
Manufacturer: Tocris 5003/50
DescriptionRho GTPase inhibitor (Kd = 354nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.
- Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
- Formula: C20H18N6O.HCl
- CAS Number: 1281870-42-5
- Solubility: Soluble to 20mM in water with gentle warming and to 100mM in DMSO
- Purity: >98
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