RIC8A Mouse anti-Human, Clone: OTI3G3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525075
DescriptionGuanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RIC8A; synembryn; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); MGC104517; MGC131931; RIC8; RIC8 protein; resistance to inhibitors of cholinesterase 8 homolog A; MGC148073; MGC148074|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of RIC8A produced in HEK293T cell|
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