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RIP3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 175631AP

Catalog No. 50-173-1647


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Description

Description

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
Specifications

Specifications

RIP3
0.17 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9QZL0, Q9Y572
Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3
Rabbit
IgG
150 μL
-20°C
Primary
11035, 56532
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
RIPK3
Liquid
Ripk3
RIP3 Fusion Protein Ag11759
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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