RIPK3 Mouse anti-Human, Clone: OTI1D9, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF803230
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCORIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
|Human recombit protein fragment corresponding to amino acids 233-518 of human RIPK3 produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|-20° C, Avoid Freeze/Thaw Cycles|
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok