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RIPK3 Mouse anti-Human, Clone: OTI3A3, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF803231

Catalog No. 50-166-6386


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
Specifications

Specifications

RIPK3
Monoclonal
Unconjugated
RIPK3
Lyophilized
RIPK3
Human recombit protein fragment corresponding to amino acids 233-518 of human RIPK3 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI3A3
PBS with 8% trehalose and no preservative; pH 7.3
Q9Y572
RIP3
Mouse
IgG2b
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11035
SDS
Documents
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