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Apexbio Technology LLC RITA (NSC 652287) 213261-59-7 50mg
Supplier: Apexbio Technology LLC A420250
RITA (NSC 652287 CAS 213261-59-7) is a synthetic thiophene-furan derivative identified for its potent antiproliferative activity particularly in renal carcinoma models Its precise molecular target remains unclear but pronounced differential cytotoxicity has been observed across tumor cell lines In vitro RITA exhibits an IC50 of 2 nM in A-498 and 20 nM in TK-10 cells with notable sensitivity compared to other lines (GI50 60 nM) In vivo subcutaneous administration in nude mice bearing A-498 xenografts resulted in complete tumor regression without detectable toxicity RITA is widely used for mechanistic studies of selective cytotoxicity and tumor biology
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