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RNF11 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550782

Catalog No. PA550782


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Description

Description

The antibody detects endogenous levels of total RNF11 protein.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates  ft.Lys-63 ft. polyubiquitin chains on RIPK1 and catalyzes the formation of  ft.Lys-48 ft.-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Specifications

Specifications

RNF11
Polyclonal
Unconjugated
RNF11
Liquid
RNF11
Full length fusion protein of Human RNF11
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1.2 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q9Y3C5
CGI-123, SID1669
Rabbit
IgG
100 μL
-20°C
Primary
26994
Documents
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