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RNF11 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548474

Catalog No. PA548474

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with bovine and mouse based on sequence homology.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates  ft.Lys-63 ft. polyubiquitin chains on RIPK1 and catalyzes the formation of  ft.Lys-48 ft.-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Specifications

Specifications

RNF11
Polyclonal
PBS with 0.09% sodium azide
Q9Y3C5
RING finger protein 11, RNF11
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
26994
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RNF11
Liquid
RNF11
KLH conjugated synthetic peptide between 64-90 amino acids from the Central region of human RNF11.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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