RNF11 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA548474

Catalog No. PA548474

Description

Predicted to react with bovine and mouse based on sequence homology.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

• Antigen: RNF11
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q9Y3C5
• Gene Symbols: RNF11
• Immunogen: KLH conjugated synthetic peptide between 64-90 amino acids from the Central region of human RNF11.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: RNF11
• Gene Alias: RING finger protein 11, RNF11
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26994
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid