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RNF144B Mouse anti-Human, Clone: OTI11F4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524994
DescriptionE3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-256 of RNF144B produced in E. coli.|
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