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RNF185 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA5107016

Catalog No. PIPA5107016


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Description

Description

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 100%

RNF185 is a E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. RNF185 acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. RNF185 protects cells from ER stress-induced apoptosis. is responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, and is preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Specifications

Specifications

RNF185
Polyclonal
Unconjugated
RNF185
Liquid
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
91445
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Q96GF1
RNF185
Synthetic peptide located within the following region: QVCPVCKAGI SRDKVIPLYG RGSTGQQDPR EKTPPRPQGQ RPEPENRGGF
Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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