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ROCK1 Mouse anti-Human, Mouse, Rat, Clone: GT261, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527778

Catalog No. PIMA527778


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Description

Description

Positive Control: 293T, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, PC-12 (30uM cisplatin for 24hr) Predicted Reactivity: Zebrafish (90%), Rabbit (98%), Chicken (96%), Rhesus Monkey (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

ROCK1 encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Specifications

Specifications

ROCK1
Monoclonal
0.15 mg/ml
PBS with no preservative
P70335, Q13464, Q63644
P160ROCK, Rho-associated, coiled-coil containing protein kinase 1, ROCK-I
Mouse
IgG1
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19877, 6093, 81762
Western Blot
GT261
Unconjugated
ROCK1
Liquid
ROCK1
Recombit protein encompassing a sequence within the N-terminus region of human ROCK1. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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