ROCK2 Mouse anti-Human, Mouse, Rat, Clone: GT11712, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527805
Positive Control: 293T, A431, HeLa, HepG2, A549 Predicted Reactivity: Xenopus laevis (80%), Rhesus Monkey (100%), Bovine (97%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ROCK2 is a protein kinase, which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.
|PBS with no preservative|
|O75116, P70336, Q62868|
|ROCK II, ROCK2, ROCK2, Rho associated coiled-coil containing protein kinase 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|19878, 25537, 9475|
|Immunohistochemistry (Paraffin), Western Blot|
|Recombit protein encompassing a sequence within the center region of human ROCK2. The exact sequence is proprietary.|
|Human, Mouse, Rat|
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