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ROR2 Mouse anti-Human, Clone: OTI4B10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527245

Catalog No. PIMA527245


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Description

Description

ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal domit skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Specifications

Specifications

ROR2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q01974
BDB, BDB1, NTRKR2, neurotrophic tyrosine kinase receptor-related 2, tyrosine-protein kinase transmembrane receptor ROR2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4920
Immunohistochemistry (Paraffin), Western Blot
OTI4B10
Unconjugated
ROR2
Liquid
ROR2
Human recombit protein fragment corresponding to amino acids 796-927 of ROR2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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