RORA Monoclonal Antibody (OTI5A6), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA803241

Catalog No. 50-167-9643

Description

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).

Specifications

• Antigen: RORA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RORA
• Gene Alias: NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6095
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Clone: OTI5A6
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P35398
• Gene Symbols: RORA
• Immunogen: Human recombit protein fragment corresponding to amino acids 98-345 of human RORA produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b