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RPRD1B Mouse anti-Human, Clone: OTI1C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526349

Catalog No. PIMA526349


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Description

Description

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3 ft. end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Specifications

Specifications

RPRD1B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NQG5
C20orf77; CREPT; NET60; dJ1057B20.2; cell cycle-related and expression-elevated protein in tumor; cell-cycle related and expression-elevated protein in tumor; regulation of nuclear pre-mRNA domain-containing protein 1B
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
58490
Immunohistochemistry (Paraffin), Western Blot
OTI1C9
Unconjugated
RPRD1B
Liquid
RPRD1B
Full length human recombit protein of RPRD1B produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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