RPS24 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 148311AP
DescriptionSerine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at ft.Ser-62 ft. and ft.Ser-67 ft., respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|P62847, P62849, P62850|
|40S ribosomal protein S24, DBA3, ribosomal protein S24, RPS24|
|20088, 6229, 81776|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|RPS24 Fusion Protein Ag6621|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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