RPSA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA586634

Catalog No. PIPA586634

Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Specifications

• Antigen: RPSA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPSA
• Gene Alias: 37 kDa laminin receptor, 37 kDa laminin receptor precursor, 37 kDa laminin receptor precursor {ECO:0000255, 37 kDa oncofetal antigen, 37/67 kDa laminin receptor, 37/67 kDa laminin receptor {ECO:0000255, 37LRP, 37LRP {ECO:0000255, 40S ribosomal protein SA, 40S ribosomal protein SA {ECO:0000255, 67 kDa laminin receptor, 67 kDa laminin receptor {ECO:0000255, 67kDa, 67LR, 67LR {ECO:0000255, AL022858, colon carcinoma laminin-binding protein, HAMAP-Rule:MF_03016}, ICAS, LAMBR, Laminin receptor 1, laminin receptor 1 (67kD, ribosomal protein SA), laminin receptor 1 (ribosomal protein SA), laminin receptor 1 {ECO:0000255, laminin-binding protein precursor p40, laminin-binding protein precursor p40 {ECO:0000255, LamR, lamR {ECO:0000255, LAMR1, Lamrl1, LBP, LBP/p40, LBP/p40 {ECO:0000255, LRP, LRP/LR, LRP/LR {ECO:0000255, MLR, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, OFA/iLRP, p40, P40-3, P40-3, functional, P40-8, P40-8, functional, ribosomal protein SA, Rpsa, rssa, SA, Small ri
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16785, 29236, 3921
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
• Gene Accession No.: P08865, P14206, P38983
• Gene Symbols: RPSA
• Immunogen: Synthetic peptide, corresponding to amino acids 181-230 of Human Laminin-R.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG